The findings indicate that LOH at MCC, DCC and YNZ22 loci may beinvolved in carcinogenesis of colorectal cancer, and LOH of DCC is frequently a late event intumor progression.

• MCC、DCC基因和YNZ22位点的LOH与大肠癌发生、发展有关，DCC基因LOH多为大肠癌的晚期改变。