The expression of c fos and c jun protein could be induced by forced swimming and venlafaxine could suppress significantly the accumulated immobility time of forced swimming.

• 强迫游泳可使大鼠下丘脑和海马内多个核团的c?fos 和c?jun 蛋白表达水平增加，而万拉法新明显缩短了强迫游泳大鼠的不动时间。