The expression of TLR4 in liver tissue was increased by D-Gal/LPS,which can be down-regulated by PDTC pretreatment. It is indicated that TLR4 might be involved in acute liver failure.

• 急性肝衰竭模型鼠TLR4表达增强,PDTC干预可下调其表达,提示TLR4在急性肝衰竭的发生发展中可能具有一定作用。