The expression of PCNA and p16 may reflect the histological differentiation status of embryonic esophageal epithelium in high-incidence area of esophageal cancer.

• 食管癌高发区人胎儿食管上皮组织中p16基因的表达和PCNA单位面积阳性细胞数与胎龄密切相关,可以客观反映食管癌高发区人胎儿食管上皮的组织分化状态。