The expression change of BOULE gene or the absence of BOULE protein brings on meiosis arrest and spermatogenic failure, which can lead to azoospermia and male infertility.

 
  • BOULE基因表达的改变或BOULE蛋白的缺乏可引起减数分裂阻滞和精子生成障碍;从而导致无精子症并产生不育.
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