The earliest work to suggest a link between BDV and human mental illness came from a serologic survey in 1985 of 285 patients with affective disorders in the United States, 694 psychiatric patients in Germany, and 200 healthy controls.

• 最早提示人类神经精神疾病与BDV感染有关的证据是来自1985年运用间接免疫荧光法所进行的血清学调查，该调查涉及美国的285例情感障碍病人和德国的694例精神病人以及200例健康对照，结果美国病人中有12例（4.；3%25），德国病人中有4例（<1%25）呈现血清阳性反应，而对照组无一例阳性。