The detailed docking for de novo ligand design and the rough docking for known chemical database screening for drug discovery. Their demands for the global minimization algorithms are different.

• 对接可分为两类:主要用于从头配体设计的细致对接和用于已知化合物数据库筛选以发现药物的粗略对接；它们对全局极小化算法的要求是不同的.