The defect was rescued by full-length APP. In contrast, overexpressionof wildtype APP at E13 accelerated migration of labeled cells into thecortical plate.

• 这种缺陷可以被完整长度的APP所逆转。在对照组中，高表达的野生型APP在胚胎第13天的时候，可以促使标记细胞迁移至皮质板。