The combination of whole-brain DTI and MRSI can in vivo detect axonal degeneration along CST in ALS patients. Measurements of FA in the SWM, CS, PV and PIC, and NAA/Cr ratios in the SWM and PV can offer the most powerful clues.

• MRSI与DTI结合能够早期定量探测ALS患者CST的轴索损伤,SWM、CS、PV和PIC平面的FA,在SWM和PV的NAA/Cr为有效的指标。