The coenzyme thiamine(vitamin B1),a natural thiazolium salt,is involved in many enzymatic catalyses.Many chemists have tried to perform enzyme mimetic symmetric carbene catalysis.

• 模拟硫胺素辅酶的卡宾立体选择性催化剂是化学家的研究热点,对近十年来手性N-杂环卡宾在对映选择性偶姻缩合中的应用进展进行研究。