The changes of intramolecular conformation of GPCRs, their coupling to G-protein and receptor dimerization represent the basic respects in GPCRs activation.

• G蛋白偶联受体的分子内构象变化与G蛋白的偶联以及受体的二聚化等是G蛋白偶联受体激活的重要基本过程。