The antiarrhythmic drug ibutilide fumarate was synthesized from aniline by methylsulfonylation, Friedel Crafts reaction, condensation, reduction and salification with an overall yield of 44%.

• 以苯胺为起始原料,经甲磺酰化、傅克反应、缩合、还原和成盐反应等5步合成了抗心律失常药富马酸伊布利特,总收率44%25(以甲磺酰苯胺计)。