The activity of PKC could be enhanced by AGEs. Conclusions AGEs can upregulate VCAM-1 expression and PKC activity of HUVECs, and increase adhesion of HUVECs to PBMCs.

• 蛋白激酶C(PKC)抑制剂可明显降低AGEs所致的VCAM-1表达增加及HUVECs-PBMCs黏附率增加。