The HPLC-MS/MS method developed in our lab was sensitive and precise. Glimepiride was well tolerated and exhibited ethnic difference between Chinese and Caucasian.

• 本文所建立的HPLC-MS/MS同时测定格列美脲及其代谢物M1的方法灵敏、准确、可靠,格列美脲耐受性较好,在国人与白种人体内的药代动力学特征存在种族差异。