The BCNU could be sustained released from BCNU-PLGA-MS over 2 weeks both in PBS and in brain tissue,and the concentrations of BCNU in ipsilateral side was 6 to 70 times higher than those in contralateral.

• BCNU-PLGA-MS在PBS和大鼠脑组织中均可持续释放药物2周以上; 缓释剂植入侧脑组织药物浓度比对侧高6~70倍;