The ASMC proliferative response to 5% CSE was dose dependently inhibited by JKC 301.Moreover,5% CSE evoked time dependent release of endogenous ET 1from ASMC.

• 内皮素A受体（ETA受体）拮抗剂JKC－301呈浓度依赖地抑制5%25CSE促ASMC增殖作用。