THI was produced by modified Feeney method (a 20g weight drops from a height of 40 cm on the parietal region) and AHS was induced by modified Wiggers method (Blood was removed from femoral artery and MAP was maintained at 40 mm Hg for 1 hour).

• 高晶体-高胶体渗透压混合液组(HHS组,n= 6)。 按照Feeney改良法制作颅脑外伤模型,经股动脉放血,使MAP降至40mm Hg左右,维持此血压1 h。