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- Surface phage display 噬菌体展示
- Objective To search for new antigens expressed on the surface of thymic stromal cells using phage display technology. 目的利用噬菌体展示技术寻找胸腺基质细胞表面的新抗原。
- The phage display antibody library is developed by reasonably combining the antibody library technology and phage surface display system. 将抗体库技术与噬菌体表面展示系统有机地结合就发展成为噬菌体展示抗体库。
- Utilizing the technology of phage surface display, special antibody can be gained from the human naive Fab phage display library, which can be used as a new therapy for tumors. 本研究构建的人天然Fab段噬菌体抗体库可为进一步筛选特异性抗体,用于免疫治疗打下基础。
- In recent years, phage display was considered for vaccine development. 近年来,呈现噬菌体开始应用于疫苗的研究。
- Recently, people have had the ability to do some research using the technology of phage display on identification of epitope sites on surface of antigens, the diagnosis and therapy of diseases, and in any other important fields. 通过噬菌体展示技术,目前人们已能借助此类文库研究包括抗原决定簇的鉴定、病的诊断与治疗等许多领域的诸多关键性问题。
- To search for liver surface inding protein of serum protein composition in idiopathic hepatitis by phage display technique,and investigate the pathogenesis of idiopathic hepatitis. 目的应用噬菌体表面展示技术寻找原因不明性肝炎血清蛋白成分在肝细胞表面的结合蛋白,探讨原因不明性肝炎发病机制。
- T1 phage displayed a higher survival than poliovirus. T1噬菌体的存活高于脊髓灰质炎病毒。
- Phage display is a new recently developed technique,in which an exogenous peptide or protein is fused with capsid protein phage and displayed on the surface of it. 噬菌体展示技术是新近发展起来的将外源肽或蛋白与特定噬菌体衣壳蛋白融合,并展示于噬菌体表面的一项新技术。
- Here, the basic mechanism and the application of phage display random peptide libraries are briefly introduced. 本文简介此类文库的基本作用原理及应用。
- Objective To screen polypeptides binding to human CD137 by biopanning phage display random heptapeptide library. 目的应用噬菌体随机七肽库筛选与人CD137特异结合的肽序列。
- Aim The phage display antibody library was constructed to obtain functional anti Fas Fab. 目的构建噬菌体抗体库,获得具有功能的抗Fas?Fab噬菌体抗体。
- Phage display random peptide library is a kind of polypeptide library developed by filamentous bacteriophages. 摘要噬菌体随机展示肽库是一类利用丝状噬菌体发展起来的多肽文库。
- Objective To screen two MUC1 antigen mimic epitopes by phage display peptide library technology. 目的从噬菌体表面展示的随机12肽库中筛选出MUC1抗原的模拟表位。
- Phage display technology is an ideal approach to the study on the protein evolution. 噬菌体展示肽库技术是研究蛋白质分子进化的理想工具。
- With the development of phage display libraries, it might be applied extensively in many fields of research. 随着此项技术的不断完善和发展,噬菌体肽库已在许多领域得到了广泛的运用。
- Methods mRNA was extracted from lymphocytes of a volunteer with high level antibody to HBsAg. Fab phage display library was constructed. 方法 采用噬菌体抗体库技术 ,从乙肝疫苗免疫后健康人外周血淋巴细胞中提取抗体基因建立抗体库 ,用纯化的HBsAg筛选Fab抗体 ;
- Ke Shen, et al. Bio-panning of HGV antigen epitope from a phage display library. Progress in Natural Science. 2000;10(6):446-450. 柯屾,等。核糖体展示技术。见:分子文库-中国生物技术丛书。沈倍奋主编。2001。北京:科学出版社。
- Conclusion The phage display technique can be applied to study the viral antigenic peptides with the advantages of simple, accuracy and rapidity. 结论噬菌体展示技术完全可应用于病毒蛋白抗原序列的筛选,并具有简便、快速、准确的优点。
- Objective To find the site of the insulin binding with the insulin receptor via biopanning of disulfide constrained phage display heptapeptides library. 目的用肽库筛选技术寻找与胰岛素受体结合的胰岛素位点。
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