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- The ability of trichloroethylene(TCE) to induce single strand breaks in peripheral lymphocytes DNA of male mice in vivo was evaluated using single cell gel electrophoresis(SCGE). 为研究三氯乙烯(TCE)的遗传毒性,应用单细胞凝胶电泳法(SCGE)测定了TCE诱导人和小鼠外周血有核细胞DNA链断裂的能力。
- Conclusion Organic extracts of CDW from three raw water sources of C river, H river and D lake in Wuhan could induce DNA strand breaks in HepG2 cells. 最高浓度氯化饮水有机提取物诱导 Hep G2 DNA损伤的强度 ;H水 >D湖和 C江 (均 P<0 .;0 1)。
- In this experiment, DNA double strand breaks induced by heavy ions in the early period were investigated with atomic force microscopy (AFM). 本实验旨在用原子力显微镜(AFM)研究重离子辐射后早期的DNA双链断裂。
- This year, the funds become more strand breaks were cherry textile merger, Leap Group crisis, Shandong Galaxy cut-off events such as the fuse. 今年以来,资金链断裂更成为樱花纺织被兼并、飞跃集团危机、山东银河停产等事件的导火索。
- Furthermore, measuring irradiationinduced DNA strand breaks with this modified method, G(SSB) and G(DSB) consisted with other researches were obtained. 以此改进方法检测电离辐射诱导的DNA单、双链断裂,可得到与其它研究结果相一致的G(SSB)和G(DSB)值。
- Methods Nick translation assay was used to detect the level of DNA strand break. 方法 用缺口翻译技术检测DNA链断裂 ,用软琼脂克隆形成率评价细胞转化。
- CAT and PARP participated in the induction of peroxidative adaptation to DNA strand break. CAT和PARP参与过氧化DNA断裂的适应诱导。
- To investigate the damage of DNA in human early chorionic villus cells in uterus induced by diagnostic ultrasound and evaluate the method used for detection of strand breaks in human DNA. 目的 :探讨诊断超声经腹照射子宫内胚胎是否引起人早孕绒毛细胞的 DNA链的损伤及评价检测DNA单、双链断裂的方法。
- Low-energy nitrogen ion irradiation can efficiently induce single-, double- strand breaks with the ratio of 6 to 1(DSB/SSB), indicating that DSB may be the main production induced by low-energy heavy ions. 能量为30keV N~+照射干燥的质粒DNA能有效的产生单链断裂(SSB)和双链断裂(DSB),有趣的是两种断裂的产额比,即DSB/SSB为6:1,说明双链断裂是低能离子引发DNA链断裂的主要形式。
- Methods After mice were fed with taurine or Vit C or Vit E respectively for 112 days, DNA strand breaks could be detected by fluorometric assay of DNA unwinding(FADU) and were compared with the control group. 方法小鼠饲料中分别添加牛磺酸、维生素C(VitC)和维生素E(VitE)喂养112d后,荧光法(FADU法)检测小鼠脾细胞DNA链的断裂程度,并与对照组比较。
- To be showed that DR significantly inhibited aflatoxin B 1(AFB 1) DNA major adduct and 2 acetylaminofluorene (2 AAF) DNA major adduct (AF ?C? 8 dG) formation as well as carcinogen induced strand breaks. 限量饮食减少小鼠肝中黄曲霉毒素B1(AFB1)?和2?乙基氨基芴(2?AAF)?DNA加合物(AF?C8?dG)的生成,同时也减少致癌物导致的DNA链断裂;
- HR can repair the DNA double strand breaks (DSBs) which is the most severe damage of DNA. It is not known whether Hp induce the occurrence of GCa by inhibiting the functions of BER genes and HR genes? HR是真核细胞修复DNA双链断裂(DNA double strand breaks, DSBs)的一个重要途径, HR相关基因的缺陷可引起DSBs修复减少,肿瘤发生率显著增加。
- Pulsed field gel electrophoresis has been applied to compare the sensitivity of B16 cells and their DNA molecules in the induction of DNA double strand breaks (DSB) by 50 MeV/u 12 C 6+ beam. 用倒转脉冲场凝胶电泳 (PIGE)比较研究了 50 Me V/u1 2 C6 +辐照小鼠 B1 6黑色素瘤细胞及其脱蛋白 DNA分子 ,从而诱导 DNA双链断裂 (DSB)的辐射敏感性。
- The NBS1 is a component of the MRE11/RAD50/NBS1 complex (MRN) and plays a critical role in the DNA double strand break (DSB) repair and the maintenance of chromosomal integrity. NBS1作为MRE11/RAD50/NBS1复合物的组分之一,是细胞应答DNA损伤的一个关键蛋白质,在DNA双链断裂修复和维持基因组稳定中发挥重要的作用。
- Apoptosis of immature thymocyte of mice induced by dexamethason and DNA strand broken cells induced by K 2Cr 2O 7 were tested by comet assay. 应用彗星试验对地塞米松诱导的小鼠胸腺凋亡细胞与重铬酸钾诱导的普通DNA链断裂损伤细胞进行了比较研究。
- Radiosensitization effect of 3-aminobenzamide( 3-AB), a specific inhibitor of ADP-ribose transferase( ADPRT), on cell colony formation and DNA double strand break (DSB), repair of human tumor cells was studied. 目的:从细胞的克隆形成能力和细胞DNA双链断裂及修复几方面探讨了ADP-核糖基转移酶(ADPRT)的特异性抑制剂3-氨基苯甲酰胺(3-AB)对人卵巢癌细胞株HOC8的放射增敏效应。 结果表明,3-AB能降低受照细胞的克隆形成能力;
- Using plasmid pGEM-3Zf(-) and M13mpl8 RF DNA, this thesis studied the DNA damage (DNA single strand break (SSB) and double strand break (DSB)), and gene mutation spectra induced by 30keV N+, C+ ions. 本文以质粒、噬菌体为实验材料,主要研究30keV的N~+、C~+引起的DNA分子损伤(单双链断裂)和它诱发基因突变的特点和规律。
- The machine must break down at this busy hour. 正忙的时候,机器偏偏又坏了。
- Objective To construct DNA double strand break(DSB) repair protein hKu70 deficient cell strain and to observe its biological characters for studying the functions of hKu 70 gene and the effects of occupational harmfulness factors on DSB repair. 目的 建立并鉴定DNA双链断裂 (DSB)修复蛋白hKu70缺陷细胞株 ,并观察该缺陷细胞的某些生物学效应 ,用于hKu70基因功能及职业有害因素对DNA双链断裂修复影响的研究。
- There were peroxidative adaptive responses to non lethal damage of high concentration H 2O 2 in both cellular viability and DNA strand break levels; but adaptive models (conditions) between the two levels were different. 在细胞活力和DNA断裂水平上均观察到非致死性适应反应,然而这两种水平的适应模式(条件)有所不同,提示两者可能存在不同的诱导适应的途径。