Starting material chrysophanol was linked to 5-fluorouracil and its derivatives were prepared a new series derivatives of bone-target antitumor compounds.

• 方法:合成大黄酚衍生物,MTT法测定其对肿瘤细胞增殖的抑制作用,用羟基磷灰石吸附试验评价该类药物的体外骨亲和性。