Sharpless of the University of North Carolina at Chapel Hill genetically engineered mice to study the effect of one of these proteins, called p16 (or, more properly, p16-Ink4a).

• Sharpless）改造小鼠的基因，以便研究其中一种肿瘤抑制蛋白p16（更正确的称呼是p16-Ink4a）的功效。