S1P is formed by phosphorylation of sphingosine catalyzed by sphingosine kinase-1 (SphK-1). And SphK-1 can be activated by a number of growth factors and intracellular oncoproteins.

• 鞘氨醇激酶-1(sphingosine kinase,SphK-1)作为S1P生物合成调节的关键限速酶,与细胞抗凋亡、增殖效应密切相关。