Ripe and plump glossy ganoderma spore is wall broken through medicine superfine breaking process and before breaking, chitinase or cellulase may be added to enzymolyze and soften spore wall.

• 筛选成熟饱满的灵芝孢子，采用机械超微粉碎等物理破碎方法进行超微破壁，亦可以在破壁前在灵芝孢子中加入几丁质酶，纤维素酶，使孢壁被酶解软化并失去韧性，再经机械方法破壁。