Rimantadine hydrochloride was synthesized from adamantane via bromination, acetylation and addition with formamide followed by hydrolysis.The overall yield was 31.5%.

• 以金刚烷为起始原料；经溴化、乙酰化、甲酰胺加成和水解反应；制得盐酸金刚乙胺；总收率31.；5%25。