Rhein inhibited transforming growth factor ?1 (TGF?1) induced plasminogen activator inhibitor 1 (PAI-1) over-expression in endothelial cells in vitro, and this effect was dose-dependent.

• 体外培养血管内皮细胞发现大黄酸能抑制TGF?1诱导的内皮细胞PAI-1的过度表达，并呈剂量依赖性。