Results:The method could effciently consider the intra-class correlation,advisably deal with the mising value,correctly obtain the estimate and standard error.

• 结果:对于临床试验重复测量资料,混合线性模型能有效的考虑数据相关性,处理有缺失值的资料,可以获得组别、时间及有无交互作用的结论。