Results There was no significant expression of Tiel and Angl in cAVM endothelial cells, while VEGF,Tie2,Ang2, PCNA and c-myc were overexpressed when compared with fetal and normal brain blood vessels.

• 结论 提示血管生成因子参与cAVM病变过程，VEGF可能通过上调c-myc表达而发挥生物学效应。 实验二、人脑动静脉畸形血管内皮细胞的体外培养和VEGF、Tie受体及血管生成素表达