Recent researches indicate that the deletion mutation of MEF2A can attenuate the transcription activation,result in the dysplasia of blood vessel endothelium and stimulate the pathogenesis of coronary artery diseases.

 
  • 近期研究表明,冠心病易感基因MEF2A的突变会影响其转录产物MEF2A蛋白的空间构象,减弱其在肌细胞信号介导的转录激活效能,进而导致血管内皮发育不良、单核细胞浸润,启动动脉粥样硬化斑块的形成。
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