Pregnancy can induce changes in physiology, metabolic isoenzymes activity, renal excretion, and plasma concentrations of drugs.So it is needed to adjust drug dosage during pregnancy.

• 摘要妊娠使人体的生理发生变化，从而影响代谢酶活性和肾排泄能力，使药物的血浆浓度发生改变，因此需要调整药物剂量。