Patients treated with ergot derivatives who had grade 3 to 4 regurgitation of any valve had received a significantly higher mean cumulative dose of pergolide or cabergoline than had patients with lower grades.

• 在服用麦角??生物进行治疗的患者中，发生任何瓣膜3到4级返流的患者服用培高利特或卡麦角林的平均累积剂量显著高于瓣膜返流级别较低的患者。