Pathological change is chronic and continual advancement,patients can emerge renal inadequacy,uraemia.excitatory autacoid and cytotoxic drug have bad curative effect and major adverse reaction.

• 病变呈慢性的进行性发展，可逐渐出现肾功能不全、尿毒症。激素、细胞毒类药物疗效欠佳，且有较大的不良反应。