Parent human lung adenocarcinoma cell A549 was more sensitive to cisplatin than drug-resistant cell line A549/DDP. Treated with different temperature, drug sensitivity of A549/DDP to cisplatin all increased.

• 亲代人肺腺癌细胞株A549对顺铂的敏感性明显高于耐药细胞株A549/DDP,不同温度加热后A549/DDP细胞对顺铂的敏感性均有提高;