P53 is an important tumor suppressor. Abnormal structure and overexpression of C-met and mutation of P53 areclosed associated with the genesis and development of many humancarcinomas.

• P53 是重要的肿瘤抑制基因,C-met 基因表达与结构的异常及 P53 基因的突变和多种人类肿瘤的发生、发展密切相关。