Our study indicates that pgp expression in NPSC was significantly induced by radiation and increases the overexpression of P-gp. Therefore, irradi- ation may be one of the reasons of crossed resistance to chemotherapy and radiotherapy.

• 放射治疗可诱导和加强鼻咽鳞癌组织中P-gp表达,这可能是引起放、化疗交叉耐药的原因之一。