Our results suggest that both CYP3A and CYP2B are involved in Nef metabolism in rats, and CYP3A plays a major role.

• 提示Nef具有酶促动力学代谢特性； CYP3A及CYP2B是介导Nef在大鼠体内生物转化的CYP450亚酶，其中主要参与Nef代谢的为CYP3A。