Our results demonstrated for the first time that Spd, the dopamine D1 receptor agonist -D2 receptor antagonist, decreased the reinforcing efficacy of cocaine.

• 我们的研究首次发现，多巴胺D1受体激动- D2受体拮抗剂左旋千金藤啶碱降低可卡因的奖赏效应；