Orthogonal project with multiple linear regression was employed to establish the relation between the amount of HPMC, Carbomer and the dissolution rate in vitro .

• 采用正交设计结合多元线性回归的方法,确定生物粘附材料羟丙甲纤维素、卡波姆的用量及配比与制剂体外释放度的关系。