One of the possible mechanism involved in perinatal of ICP is apoptosis caused by overexpression of bax in syncytiotrophoblast leading placental dysfunction.

• ICP患者胎盘合体滋养细胞bax基因过度表达,胎盘细胞凋亡率升高,影响胎盘功能,可能是ICP并发围生儿缺氧的病理生理基础之一。