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- Research advances in selectively replicating oncolytic adenoviruses as cancer therapeutics 肿瘤特异增殖病毒的研究进展
- Keywords Oncolytic adenoviruses;Cancer gene therapy;Transcriptional regulation;Tumor or tissue-specific promote; 溶瘤病毒;肿瘤基因治疗;转录调节;肿瘤特异性启动子;
- Oncolytic adenoviruses 溶瘤病毒
- Here we construct a hTERT and Cox-2 promoter regulated oncolytic virus byreplace the endogenous adenovirus El a and Elb promoter respectively. 为下一步进行腺病毒在293细胞的包装、纯化、以及病毒感染各种肿瘤细胞、病毒感染治疗动物实体瘤模型奠定基础。
- Objective: To evaluate the selectively oncolytic effect of conditionally replicating adenovirus CNHK500 in breast cancer. 目的: 观察选择性增殖腺病毒CNHK500对乳腺癌的特异性杀伤作用。
- It is, therefore, feasible to exploit IL-8 promoter to control the replication of oncolytic adenovirus aiming to achieve more tumor-targeted oncolysis for treating NSCLC. 因此，在非小细胞肺癌中以介白素八调控子控制溶瘤腺病毒应可具有更佳的肿瘤专一性与溶瘤效果。
- Adenoviruses are the only enteric viruses that contain a DNA core. 腺病毒是唯一含有DNA核心的肠道病毒。
- Adenoviruses are the only enteric viruses that contain a DNA core . 腺病毒是唯一含有DNA核心的肠道病毒。
- Adenovirus mediated angiostatin gene therapy for rat glioma. 重组腺病毒载体介导血管抑素基因治疗大鼠脑胶质瘤的实验研究。
- Adenovirus and parainfluenza virus are common viruses in the community. 腺病毒及副流感都常见于社区。
- Moreover, the expression of CAR has close relationship with tumor prognosis and cytoreduction mediated by adenoviruses. 而且，CAR的表达与肿瘤的预后和腺病毒介导的减瘤效应也有密切的关系。
- Tremendous advances have been made in developing oncolytic viruses in the last few years. 近几年溶瘤病毒的研究有很大进展。
- Soon the viral DNA directs the cell to make copies of the viral DNA, synthesize viral proteins and combine the two into billions of new adenoviruses. 不久，病毒的DNA就会指挥细胞制造病毒DNA及合成病毒蛋白，并将两者结合，形成数十亿个新的腺病毒。
- In this review,tumor targeting,killing efficiency,safety and the evaluation of oncolytic viruses therapy are discussed. 文章简要综述了溶瘤病毒肿瘤治疗的靶向性、杀伤性、安全性和疗效监测。
- Among these,there were l5 6 strains of poliovir- uses,10 of coxsackie viruses,8 ECHO viruses,8 adenoviruses,7 Enteroviruses 71 and 3 strains undefined. 柯萨奇病毒10株，埃可病毒和腺病毒各8株，肠道71型病毒7株，未定型病毒3株。
- Keywords adenovirus;transductional control;oncolytic; 腺病毒;转导调节;溶瘤;
- The initial discovery of the virus' oncolytic properties were limited to only a few types of cancer. 有些典当行甚至集典当、担保、评估、拍卖于一体。按陈先生的话来说，同样的'当'字如今早已有了不同的涵义。
- And adenoviruses that are designed to bind to receptors on the surfaces of tumor cells can still invade a small proportion of healthy cells. 同时，设计成能与肿瘤细胞表面受体结合的腺病毒，仍然可能侵犯小部份的正常细胞。
- The modified adenoviruses can infect the particular site of the liver cells where HBV replicates, but the adenoviruses themselves do not replicate. 被修改过的腺病毒可以感染某个部位，HBV在复制中的肝细胞，但是腺病毒自身并不复制。
- Two methods of delivery are being tried: liposomes and adenoviruses, both delivered with an aerosol inhaler, like those used by asthmatics. 目前诊断手段有抽取羊水进行基因分析或者粪便含盐度测试。
