Objectives To investigate the relationship of the human calcium-activated chloride channel 1 (CaCC_1) and mucus overproduction in the airway of Chinese patients with COPD, the expression of CaCC_1, MUC5AC and mucus in bronchial tissues were examined.

• 目的 通过检测慢性阻塞性肺疾病(COPD)患者气道上皮的Ca~(2+)激活的氯离子通道1(CaCC_1)和黏蛋白MUC5AC、黏膜下腺黏蛋白的表达，以探讨COPD患者气道黏液高分泌的机制。