Objectives To assess the clinical efficacy and safety of plasma exchange combined with methotrexate (MTX) and sulfasalazine (SSZ) in the treatment of severe rheumatoid arthritis (RA).

• 摘要目的：评价血浆置换联合甲氨蝶呤(MTX)、柳氮磺胺吡啶(SSZ)与单纯甲氨蝶呤、柳氮磺胺吡啶治疗重症类风湿关节炎的疗效与安全性。