Objective:To establish the typical model of chronic cor pulmonale and study the effect of antibodies to M2-muscarinic receptor(M2-Ab)to the cardiac function.

• 目的:通过建立大鼠肺心病模型和离体灌流心脏,观察M2受体自身抗体对心脏功能的影响,进一步探讨M2受体抗体在肺心病发病中的机制。