Objective: To Establish a Balb/c mouse model of HSE and learn the expression of inducible nitric oxide synthase, then study the effect of AMG, an inhibitor of iNOS, on the HSE of Balb/c mice, so explore the pathogenesis of HSE.

• 因此，本实验拟建立稳定的Balb/c小鼠HSE模型，了解病程中iNOS表达的变化，观察给予AMG后HSE小鼠的临床表现及发病率变化，进一步探讨NO参与HSE的发病机制。