Objective: Diabetic nephropathy (DN), as a serious chronic microvascular implication of diabetes, has become one of the main etiological factors resulting in end stage of renal failure with the increasing incidence of diebets worldwide.

• 目的:糖尿病肾病(diabetic nephropathy,DN)是糖尿病常见和严重的慢性微血管并发症,它已成为终末期肾功能衰竭(end-stage renal failure,ESRF)的主要原因之一,因而探索糖尿病肾病的发病机制及其防治方法是当今肾病学者热切关注的课题。