Objective To prepare transgenic mice model of human (Swedish mutation of amyloid precursor protein, APP SWE ) gene. Methods By pronuclear microinjection, human APP SWE genes were microinjected into pronuclei of zygotes of C57 and Kunming white mice.

• 目的 建立携带人类淀粉样前体蛋白瑞典型突变 (Swedish mutation of amyloid precursorprotein,APPSWE)基因的转基因小鼠模型。