Objective To investigate the suppression of MDR1 and P-glycoprotein induced by small interfering RNA and the restoration of sensitivity to chemotherapeutic drugs in multidrug-resistant hepatocellular carcinoma cell line Bel7402/5-Fu.

• 目的:研究小片段RNA干扰对肝癌耐药细胞系Bel7402/5-Fu中多药耐药基因(multidrugresistance1,MDR1)及其蛋白产物P-gp表达的抑制作用和逆转其耐药性的效果。