Objective To investigate the effects of HDTIC-1 and HDTIC-2 isolated from Astragali Radix on the expression of p16 and p21 of human fetal lung diploid fibroblasts(2BS) so as to explore the mechanism of HDTIC delaying replicative senescence.

• 目的观察黄芪碱化合物HDTIC-1和2对人胚肺二倍体成纤维细胞(2BS)p16、p21表达的影响,以探讨其延缓复制性衰老的分子机制。