Objective To compare the efficacy and the risk of hypoglycemia of glargine quaque die and mixed insulin bis in die on the condition of controlling the blood glucose unsuccessfully with oral drugs.

• 目的在口服降糖药不能良好控制血糖的情况下,加用每日1次甘精胰岛素或加用每日2次预混胰岛素治疗,比较这两种方案的疗效和低血糖的风险。