Objecties: We hypothesized that deletion or pharmacologic inhibition of PI3K would impair the lung inflammatory response to the prototypic gram-positie bacterial pathogen Streptococcus pneumoniae.

• 目的：我们假设敲除或者药物抑制PI3K将损害肺脏对于革兰氏阳性菌肺炎链球菌的炎症反应。