OBJECTIVE To develop a sensitive and specific LCMS/MS method for the determination of didanosine in human plasma and to study the bioequivalence of different formulations containing didanosine.

• 目的建立测定人血浆中去羟肌苷的液相色谱-质谱/质谱联用法(LC-MS/MS),并应用于药物制剂生物等效性评价。